論文 - 詳細
| RRC ID | 31990 |
|---|---|
| 著者 | Hayashi S, Inoue Y, Kiyonari H, Abe T, Misaki K, Moriguchi H, Tanaka Y, Takeichi M. |
| タイトル | Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts. |
| ジャーナル | Dev Cell |
| Abstract |
In the process of neuronal wiring, axons derived from the same functional group typically extend together, resulting in fascicle formation. How these axons communicate with one another remains largely unknown. Here, we show that protocadherin-17 (Pcdh17) supports this group extension by recruiting actin polymerization regulators to interaxonal contact sites. Pcdh17 is expressed by a subset of amygdala neurons, and it accumulates at axon-axon boundaries because of homophilic binding. Pcdh17 knockout in mice suppressed the extension of these axons. Ectopically expressed Pcdh17 altered the pattern of axon extension. In in-vitro cultures, wild-type growth cones normally migrate along other axons, whereas Pcdh17 null growth cones do not. Pcdh17 recruits the WAVE complex, Lamellipodin, and Ena/VASP to cell-cell contacts, converting these sites into motile structures. We propose that, through these mechanisms, Pcdh17 maintains the migration of growth cones that are in contact with other axons, thereby supporting their collective extension. |
| 巻・号 | 30(6) |
| ページ | 673-87 |
| 公開日 | 2014-9-29 |
| DOI | 10.1016/j.devcel.2014.07.015 |
| PII | S1534-5807(14)00457-2 |
| PMID | 25199687 |
| MeSH | Actins / metabolism* Amygdala / cytology Amygdala / growth & development Amygdala / metabolism Animals Axons / metabolism* Axons / physiology Cadherins / genetics Cadherins / metabolism* Cell Movement DNA-Binding Proteins / metabolism Growth Cones / metabolism* Growth Cones / physiology Mice Protocadherins Wiskott-Aldrich Syndrome Protein Family / metabolism |
| IF | 10.092 |
| 引用数 | 45 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pCAH-Pcdh17-EGFP (RDB13049) pCAP-Lamellipodin-His (RDB13050). |