Reference - Detail
RRC ID | 32000 |
---|---|
Author | Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M. |
Title | Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection. |
Journal | J Virol |
Abstract |
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells. |
Volume | 89(2) |
Pages | 1468-73 |
Published | 2015-1-15 |
DOI | 10.1128/JVI.02293-14 |
PII | JVI.02293-14 |
PMID | 25378499 |
PMC | PMC4300674 |
MeSH | Animals Antibodies, Neutralizing / blood* Antibodies, Viral / blood* CD4-Positive T-Lymphocytes / immunology Cytidine Deaminase / deficiency Friend murine leukemia virus / immunology* Immunization, Passive Immunoglobulin Class Switching Immunoglobulin M / immunology Leukemia, Experimental / immunology* Leukemia, Experimental / virology Mice Retroviridae Infections / immunology* Retroviridae Infections / virology Somatic Hypermutation, Immunoglobulin* Tumor Virus Infections / immunology* Tumor Virus Infections / virology |
IF | 4.501 |
Times Cited | 5 |
WOS Category | VIROLOGY |
Resource | |
Mice | RBRC00897 RBRC00901 |