RRC ID 32227
Author Tanaka Y, Yazawa K, Dabbs ER, Nishikawa K, Komaki H, Mikami Y, Miyaji M, Morisaki N, Iwasaki S.
Title Different rifampicin inactivation mechanisms in Nocardia and related taxa.
Journal Microbiol. Immunol.
Abstract Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.
Volume 40(1)
Pages 1-4
Published 1996
PMID 8871521
MeSH Actinomycetales / drug effects* Actinomycetales / metabolism Drug Resistance, Microbial Glycosylation Microbial Sensitivity Tests Phosphorylation Rifampin / chemistry Rifampin / pharmacology* Species Specificity
IF 1.335
Times Cited 27
Pathogenic microorganisms IFM 0025 IFM 0132 IFM 0147 IFM 0149 IFM 0150 IFM 0161 IFM 0162 IFM 0259 IFM 0359 IFM 0405 IFM 0413 IFM 0414 IFM 0433 IFM 0451 IFM 0452 IFM 0453 IFM 0454 IFM 0473 IFM 0474 IFM 0475 IFM 0476 IFM 0477 IFM 0478 IFM 0479 IFM 2057