論文 - 詳細
| RRC ID | 32236 |
|---|---|
| 著者 | Jeney V, Ramos S, Bergman ML, Bechmann I, Tischer J, Ferreira A, Oliveira-Marques V, Janse CJ, Rebelo S, Cardoso S, Soares MP. |
| タイトル | Control of disease tolerance to malaria by nitric oxide and carbon monoxide. |
| ジャーナル | Cell Rep |
| Abstract |
Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection. Here, we addressed the mechanism underlying their protective effect against experimental cerebral malaria (ECM), a severe form of malaria that develops in Plasmodium-infected mice, which resembles, in many aspects, human cerebral malaria (CM). NO suppresses the pathogenesis of ECM via a mechanism involving (1) the transcription factor nuclear factor erythroid 2-related factor 2 (NRF-2), (2) induction of heme oxygenase-1 (HO-1), and (3) CO production via heme catabolism by HO-1. The protection afforded by NO is associated with inhibition of CD4(+) T helper (TH) and CD8(+) cytotoxic (TC) T cell activation in response to Plasmodium infection via a mechanism involving HO-1 and CO. The protective effect of NO and CO is not associated with modulation of host pathogen load, suggesting that these gasotransmitters establish a crosstalk-conferring disease tolerance to Plasmodium infection. |
| 巻・号 | 8(1) |
| ページ | 126-36 |
| 公開日 | 2014-7-10 |
| DOI | 10.1016/j.celrep.2014.05.054 |
| PII | S2211-1247(14)00448-3 |
| PMID | 24981859 |
| MeSH | Animals CD8-Positive T-Lymphocytes / drug effects CD8-Positive T-Lymphocytes / immunology Carbon Monoxide / metabolism Carbon Monoxide / pharmacology* Carbon Monoxide / therapeutic use Heme Oxygenase-1 / genetics Heme Oxygenase-1 / metabolism Immune Tolerance* Lymphocyte Activation Malaria, Cerebral / drug therapy Malaria, Cerebral / immunology* Mice Mice, Inbred C57BL NF-E2-Related Factor 2 / genetics NF-E2-Related Factor 2 / metabolism Nitric Oxide / pharmacology* Nitric Oxide / therapeutic use T-Lymphocytes, Cytotoxic / drug effects T-Lymphocytes, Cytotoxic / immunology T-Lymphocytes, Helper-Inducer / drug effects T-Lymphocytes, Helper-Inducer / immunology |
| IF | 8.109 |
| 引用数 | 39 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01390 |