論文 - 詳細
| RRC ID | 32387 |
|---|---|
| 著者 | Kim MJ, Choe KM. |
| タイトル | Basement membrane and cell integrity of self-tissues in maintaining Drosophila immunological tolerance. |
| ジャーナル | PLoS Genet |
| Abstract |
The mechanism underlying immune system recognition of different types of pathogens has been extensively studied over the past few decades; however, the mechanism by which healthy self-tissue evades an attack by its own immune system is less well-understood. Here, we established an autoimmune model of melanotic mass formation in Drosophila by genetically disrupting the basement membrane. We found that the basement membrane endows otherwise susceptible target tissues with self-tolerance that prevents autoimmunity, and further demonstrated that laminin is a key component for both structural maintenance and the self-tolerance checkpoint function of the basement membrane. Moreover, we found that cell integrity, as determined by cell-cell interaction and apicobasal polarity, functions as a second discrete checkpoint. Target tissues became vulnerable to blood cell encapsulation and subsequent melanization only after loss of both the basement membrane and cell integrity. |
| 巻・号 | 10(10) |
| ページ | e1004683 |
| 公開日 | 2014-10-1 |
| DOI | 10.1371/journal.pgen.1004683 |
| PII | PGENETICS-D-14-00776 |
| PMID | 25329560 |
| PMC | PMC4199487 |
| MeSH | Animals Animals, Genetically Modified Autoimmunity / genetics Basement Membrane / cytology* Basement Membrane / immunology Cell Communication Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / immunology* Immune Tolerance* Laminin / genetics Laminin / metabolism Larva / immunology RNA Interference |
| IF | 5.175 |
| 引用数 | 8 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 16858R-3 12497R-1 12908R-3 1771R-1 16827R-2 1762R-1 1560R-1 8470R-4 11990R-2 1725R-1 5803R-1 |