RRC ID 324
著者 Sugimura K, Satoh D, Estes P, Crews S, Uemura T.
タイトル Development of morphological diversity of dendrites in Drosophila by the BTB-zinc finger protein abrupt.
ジャーナル Neuron
Abstract Morphological diversity of dendrites contributes to specialized functions of individual neurons. In the present study, we examined the molecular basis that generates distinct morphological classes of Drosophila dendritic arborization (da) neurons. da neurons are classified into classes I to IV in order of increasing territory size and/or branching complexity. We found that Abrupt (Ab), a BTB-zinc finger protein, is expressed selectively in class I cells. Misexpression of ab in neurons of other classes directed them to take the appearance of cells with smaller and/or less elaborated arbors. Loss of ab functions in class I neurons resulted in malformation of their typical comb-like arbor patterns and generation of supernumerary branch terminals. Together with the results of monitoring dendritic dynamics of ab-misexpressing cells or ab mutant ones, all of the data suggested that Ab endows characteristics of dendritic morphogenesis of the class I neurons.
巻・号 43(6)
ページ 809-22
公開日 2004-9-16
DOI 10.1016/j.neuron.2004.08.016
PII S0896627304005240
PMID 15363392
MeSH Animals Animals, Genetically Modified Dendrites / physiology* Drosophila Drosophila Proteins / metabolism Drosophila Proteins / physiology* Embryo, Nonmammalian Fushi Tarazu Transcription Factors Gene Expression Regulation, Developmental / physiology Green Fluorescent Proteins Homeodomain Proteins Immunohistochemistry / methods Larva Luminescent Proteins / metabolism Morphogenesis / physiology* Nerve Tissue Proteins / metabolism Neurons / classification Neurons / cytology* Neurons / physiology Nuclear Proteins / metabolism Recombinant Fusion Proteins / metabolism Time Factors Trans-Activators / metabolism Transcription Factors Zinc Fingers / physiology*
IF 14.415
引用数 77
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ DGRC#103907