論文 - 詳細
| RRC ID | 32412 |
|---|---|
| 著者 | Foronda D, Weng R, Verma P, Chen YW, Cohen SM. |
| タイトル | Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. |
| ジャーナル | Genes Dev |
| Abstract |
Homeostasis of the intestine is maintained by dynamic regulation of a pool of intestinal stem cells. The balance between stem cell self-renewal and differentiation is regulated by the Notch and insulin signaling pathways. Dependence on the insulin pathway places the stem cell pool under nutritional control, allowing gut homeostasis to adapt to environmental conditions. Here we present evidence that miR-305 is required for adaptive homeostasis of the gut. miR-305 regulates the Notch and insulin pathways in the intestinal stem cells. Notably, miR-305 expression in the stem cells is itself under nutritional control via the insulin pathway. This link places regulation of Notch pathway activity under nutritional control. These findings provide a mechanism through which the insulin pathway controls the balance between stem cell self-renewal and differentiation that is required for adaptive homeostasis in the gut in response to changing environmental conditions. |
| 巻・号 | 28(21) |
| ページ | 2421-31 |
| 公開日 | 2014-11-1 |
| DOI | 10.1101/gad.241588.114 |
| PII | 28/21/2421 |
| PMID | 25367037 |
| PMC | PMC4215186 |
| MeSH | Animal Nutritional Physiological Phenomena Animals Cell Differentiation Cell Proliferation Drosophila / cytology Drosophila / genetics Drosophila / metabolism Drosophila / physiology* Drosophila Proteins / metabolism* Gene Expression Regulation Gene Knockout Techniques Homeostasis / genetics* Insulin / metabolism* Intestinal Mucosa / metabolism* MicroRNAs / genetics MicroRNAs / metabolism* Receptors, Notch / metabolism* Signal Transduction Stem Cells / cytology* Stem Cells / metabolism |
| IF | 9.527 |
| 引用数 | 33 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#114226 |