論文 - 詳細
| RRC ID | 32416 |
|---|---|
| 著者 | Redt-Clouet C, Trannoy S, Boulanger A, Tokmatcheva E, Savvateeva-Popova E, Parmentier ML, Preat T, Dura JM. |
| タイトル | Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila. |
| ジャーナル | Eur J Neurosci |
| Abstract |
The remodelling of neurons during their development is considered necessary for their normal function. One fundamental mechanism involved in this remodelling process in both vertebrates and invertebrates is axon pruning. A well-documented case of such neuronal remodelling is the developmental axon pruning of mushroom body γ neurons that occurs during metamorphosis in Drosophila. The γ neurons undergo pruning of larval-specific dendrites and axons at metamorphosis, followed by their regrowth as adult-specific dendrites and axons. We recently revealed a molecular cascade required for this pruning. The nuclear receptor ftz-f1 activates the expression of the steroid hormone receptor EcR-B1, a key component for γ remodelling, and represses expression of Hr39, an ftz-f1 homologous gene. If ectopically expressed in the γ neurons, HR39 inhibits normal pruning, probably by competing with endogenous FTZ-F1, which results in decreased EcR-B1 expression. The mushroom bodies are a bilaterally symmetric structure in the larval and adult brain and are involved in the processing of different types of olfactory memory. How memory is affected in pruning-deficient adult flies that possess larval-stage neuronal circuitry will help to explain the functional role of neuron remodelling. Flies overexpressing Hr39 are viable as adults and make it possible to assess the requirement for wild-type mushroom body pruning in memory. While blocking mushroom body neuron remodelling impaired memory after short-term courtship conditioning, long-term memory was normal. These results show that larval pruning is necessary for adult memory and that expression of courtship short-term memory and long-term memory may be parallel and independent. |
| 巻・号 | 35(11) |
| ページ | 1684-91 |
| 公開日 | 2012-6-1 |
| DOI | 10.1111/j.1460-9568.2012.08103.x |
| PMID | 22571719 |
| MeSH | Animals Cell Differentiation / physiology* Drosophila melanogaster / cytology Drosophila melanogaster / growth & development* Drosophila melanogaster / physiology Female Male Memory, Long-Term / physiology* Mushroom Bodies / cytology Mushroom Bodies / growth & development* Mushroom Bodies / physiology Neuronal Plasticity / physiology* Neurons / cytology Neurons / physiology Sexual Behavior, Animal / physiology* |
| IF | 3.115 |
| 引用数 | 10 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#202206 |