| RRC ID |
32439
|
| 著者 |
Ayukawa T, Akiyama M, Mummery-Widmer JL, Stoeger T, Sasaki J, Knoblich JA, Senoo H, Sasaki T, Yamazaki M.
|
| タイトル |
Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila.
|
| ジャーナル |
Cell Rep
|
| Abstract |
In Drosophila, planar cell polarity (PCP) molecules such as Dachsous (Ds) may function as global directional cues directing the asymmetrical localization of PCP core proteins such as Frizzled (Fz). However, the relationship between Ds asymmetry and Fz localization in the eye is opposite to that in the wing, thereby causing controversy regarding how these two systems are connected. Here, we show that this relationship is determined by the ratio of two Prickle (Pk) isoforms, Pk and Spiny-legs (Sple). Pk and Sple form different complexes with distinct subcellular localizations. When the amount of Sple is increased in the wing, Sple induces a reversal of PCP using the Ds-Ft system. A mathematical model demonstrates that Sple is the key regulator connecting Ds and the core proteins. Our model explains the previously noted discrepancies in terms of the differing relative amounts of Sple in the eye and wing.
|
| 巻・号 |
8(2)
|
| ページ |
610-21
|
| 公開日 |
2014-7-24
|
| DOI |
10.1016/j.celrep.2014.06.009
|
| PII |
S2211-1247(14)00477-X
|
| PMID |
24998533
|
| MeSH |
Animals
Cadherins / genetics
Cadherins / metabolism*
Cell Polarity*
Compound Eye, Arthropod / cytology
Compound Eye, Arthropod / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Drosophila / genetics
Drosophila / metabolism
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
LIM Domain Proteins / genetics
LIM Domain Proteins / metabolism*
Models, Genetic
Organ Specificity
Protein Isoforms / genetics
Protein Isoforms / metabolism
Protein Transport
Wings, Animal / cytology
Wings, Animal / metabolism
|
| IF |
8.109
|
| 引用数 |
33
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
|
