Reference - Detail
| RRC ID | 32496 |
|---|---|
| Author | Lin ST, Zhang L, Lin X, Zhang LC, Garcia VE, Tsai CW, Ptáček L, Fu YH. |
| Title | Nuclear envelope protein MAN1 regulates clock through BMAL1. |
| Journal | Elife |
| Abstract |
Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathways is far from exhaustive. In recent decades, the nuclear envelope has emerged as a global gene regulatory machine, although its role in circadian regulation has not been explored. We report that transcription of the core clock component BMAL1 is positively modulated by the inner nuclear membrane protein MAN1, which directly binds the BMAL1 promoter and enhances its transcription. Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions. |
| Volume | 3 |
| Pages | e02981 |
| Published | 2014-9-2 |
| DOI | 10.7554/eLife.02981 |
| PMID | 25182847 |
| PMC | PMC4150126 |
| MeSH | ARNTL Transcription Factors / genetics* ARNTL Transcription Factors / metabolism Animals Blotting, Western Cell Line, Tumor Circadian Clocks / genetics* DNA-Binding Proteins Gene Expression Regulation* HEK293 Cells Humans Lamin Type B / genetics Lamin Type B / metabolism Membrane Proteins / genetics* Membrane Proteins / metabolism Mice, Inbred C57BL Mice, Knockout Nuclear Envelope / metabolism Nuclear Proteins / genetics* Nuclear Proteins / metabolism Promoter Regions, Genetic / genetics Protein Binding RNA Interference Reverse Transcriptase Polymerase Chain Reaction |
| IF | 7.08 |
| Times Cited | 14 |
| WOS Category | BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#200396 DGRC#205055 3167R-1 |