論文 - 詳細
| RRC ID | 32500 |
|---|---|
| 著者 | Jukam D, Xie B, Rister J, Terrell D, Charlton-Perkins M, Pistillo D, Gebelein B, Desplan C, Cook T. |
| タイトル | Opposite feedbacks in the Hippo pathway for growth control and neural fate. |
| ジャーナル | Science |
| Abstract |
Signaling pathways are reused for multiple purposes in plant and animal development. The Hippo pathway in mammals and Drosophila coordinates proliferation and apoptosis via the coactivator and oncoprotein YAP/Yorkie (Yki), which is homeostatically regulated through negative feedback. In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes. Here, we show that this all-or-nothing neuronal differentiation results from Hippo pathway positive feedback: Yki both represses its negative regulator, warts, and promotes its positive regulator, melted. This postmitotic Hippo network behavior relies on a tissue-restricted transcription factor network-including a conserved Otx/Orthodenticle-Nrl/Traffic Jam feedforward module-that allows Warts-Yki-Melted to operate as a bistable switch. Altering feedback architecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in development and evolution. |
| 巻・号 | 342(6155) |
| ページ | 1238016 |
| 公開日 | 2013-10-11 |
| DOI | 10.1126/science.1238016 |
| PII | science.1238016 |
| PMID | 23989952 |
| PMC | PMC3796000 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Feedback, Physiological Gene Expression Regulation, Developmental* Gene Regulatory Networks Homeodomain Proteins / metabolism Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Mitosis Neurogenesis / genetics* Nuclear Proteins / metabolism* Photoreceptor Cells, Invertebrate / cytology Photoreceptor Cells, Invertebrate / metabolism Photoreceptor Cells, Invertebrate / physiology* Protein Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Signal Transduction* Trans-Activators / metabolism* YAP-Signaling Proteins |
| IF | 41.846 |
| 引用数 | 48 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 12399R-2 |