論文 - 詳細
| RRC ID | 32503 |
|---|---|
| 著者 | Chanut-Delalande H, Hashimoto Y, Pelissier-Monier A, Spokony R, Dib A, Kondo T, Bohère J, Niimi K, Latapie Y, Inagaki S, Dubois L, Valenti P, Polesello C, Kobayashi S, Moussian B, White KP, Plaza S, Kageyama Y, Payre F. |
| タイトル | Pri peptides are mediators of ecdysone for the temporal control of development. |
| ジャーナル | Nat Cell Biol |
| Abstract |
Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal control remain poorly understood. Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the steroid hormone ecdysone for the timing of developmental programs in Drosophila. We identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development, through post-translational control of the Shavenbaby transcription factor. We show that manipulating pri expression is sufficient to either put on hold or induce premature differentiation of trichomes. Furthermore, we find that ecdysone-dependent regulation of pri is not restricted to epidermis and occurs over various tissues and times. Together, these findings provide a molecular framework to explain how systemic hormonal control coordinates specific programs of differentiation with developmental timing. |
| 巻・号 | 16(11) |
| ページ | 1035-44 |
| 公開日 | 2014-11-1 |
| DOI | 10.1038/ncb3052 |
| PII | ncb3052 |
| PMID | 25344753 |
| MeSH | Animals Arrestins / genetics Arrestins / metabolism* Cell Differentiation / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Ecdysone / genetics Ecdysone / metabolism* Gene Expression Regulation, Developmental / physiology* Glutathione Transferase / genetics Glutathione Transferase / metabolism* Mutation / genetics Receptors, Steroid / genetics Receptors, Steroid / metabolism* Signal Transduction / physiology Transaldolase / genetics Transaldolase / metabolism |
| IF | 20.042 |
| 引用数 | 40 |
| WOS 分野 | CELL BIOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 5.0 |
| リソース情報 | |
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