| RRC ID |
32511
|
| Author |
Yamagata N, Ichinose T, Aso Y, Plaçais PY, Friedrich AB, Sima RJ, Preat T, Rubin GM, Tanimoto H.
|
| Title |
Distinct dopamine neurons mediate reward signals for short- and long-term memories.
|
| Journal |
Proc Natl Acad Sci U S A
|
| Abstract |
Drosophila melanogaster can acquire a stable appetitive olfactory memory when the presentation of a sugar reward and an odor are paired. However, the neuronal mechanisms by which a single training induces long-term memory are poorly understood. Here we show that two distinct subsets of dopamine neurons in the fly brain signal reward for short-term (STM) and long-term memories (LTM). One subset induces memory that decays within several hours, whereas the other induces memory that gradually develops after training. They convey reward signals to spatially segregated synaptic domains of the mushroom body (MB), a potential site for convergence. Furthermore, we identified a single type of dopamine neuron that conveys the reward signal to restricted subdomains of the mushroom body lobes and induces long-term memory. Constant appetitive memory retention after a single training session thus comprises two memory components triggered by distinct dopamine neurons.
|
| Volume |
112(2)
|
| Pages |
578-83
|
| Published |
2015-1-13
|
| DOI |
10.1073/pnas.1421930112
|
| PII |
1421930112
|
| PMID |
25548178
|
| PMC |
PMC4299218
|
| MeSH |
Animals
Animals, Genetically Modified
Appetitive Behavior / physiology
Carbohydrates
Dopaminergic Neurons / physiology*
Drosophila melanogaster / anatomy & histology
Drosophila melanogaster / genetics
Drosophila melanogaster / physiology*
Female
Learning / physiology
Memory, Long-Term / physiology
Memory, Short-Term / physiology
Mushroom Bodies / physiology
Odorants
Reward
Smell / physiology
Taste / physiology
|
| IF |
9.412
|
| Times Cited |
89
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| Drosophila |
|
