| RRC ID |
32533
|
| 著者 |
Hiroi M, Ohkura M, Nakai J, Masuda N, Hashimoto K, Inoue K, Fiala A, Tabata T.
|
| タイトル |
Principal component analysis of odor coding at the level of third-order olfactory neurons in Drosophila.
|
| ジャーナル |
Genes Cells
|
| Abstract |
Olfactory information in Drosophila is conveyed by projection neurons from olfactory sensory neurons to Kenyon cells (KCs) in the mushroom body (MB). A subset of KCs responds to a given odor molecule, and the combination of these KCs represents a part of the neuronal olfactory code. KCs are also thought to function as coincidence detectors for memory formation, associating odor information with a coincident punishment or reward stimulus. Associative conditioning has been shown to modify KC output. This plasticity occurs in the vertical lobes of MBs containing α/α' branches of KCs, which is shown by measuring the average Ca(2+) levels in the branch of each lobe. We devised a method to quantitatively describe the population activity patterns recorded from axons of >1000 KCs at the α/α' branches using two-photon Ca(2+) imaging. Principal component analysis of the population activity patterns clearly differentiated the responses to distinct odors.
|
| 巻・号 |
18(12)
|
| ページ |
1070-81
|
| 公開日 |
2013-12-1
|
| DOI |
10.1111/gtc.12094
|
| PMID |
24118654
|
| MeSH |
Animals
Axons / physiology
Cyclohexanols / pharmacology
Drosophila / physiology*
Mushroom Bodies / cytology
Mushroom Bodies / physiology
Octanols / pharmacology
Odorants*
Olfactory Receptor Neurons / physiology*
Principal Component Analysis
Smell
|
| IF |
1.655
|
| 引用数 |
4
|
|
WOS 分野
|
GENETICS & HEREDITY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
OK107 gal4 driver |
