論文 - 詳細
| RRC ID | 32543 |
|---|---|
| 著者 | You J, Zhang Y, Li Z, Lou Z, Jin L, Lin X. |
| タイトル | Drosophila perlecan regulates intestinal stem cell activity via cell-matrix attachment. |
| ジャーナル | Stem Cell Reports |
| Abstract |
Stem cells require specialized local microenvironments, termed niches, for normal retention, proliferation, and multipotency. Niches are composed of cells together with their associated extracellular matrix (ECM). Currently, the roles of ECM in regulating niche functions are poorly understood. Here, we demonstrate that Perlecan (Pcan), a highly conserved ECM component, controls intestinal stem cell (ISC) activities and ISC-ECM attachment in Drosophila adult posterior midgut. Loss of Pcan from ISCs, but not other surrounding cells, causes ISCs to detach from underlying ECM, lose their identity, and fail to proliferate. These defects are not a result of a loss of epidermal growth factor receptor (EGFR) or Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling activity but partially depend on integrin signaling activity. We propose that Pcan secreted by ISCs confers niche properties to the adjacent ECM that is required for ISC maintenance of stem cell identity, activity, and anchorage to the niche. |
| 巻・号 | 2(6) |
| ページ | 761-9 |
| 公開日 | 2014-6-3 |
| DOI | 10.1016/j.stemcr.2014.04.007 |
| PII | S2213-6711(14)00114-3 |
| PMID | 24936464 |
| PMC | PMC4050351 |
| MeSH | Animals Drosophila Drosophila Proteins / metabolism* ErbB Receptors / metabolism Extracellular Matrix / metabolism* Heparan Sulfate Proteoglycans / metabolism* Intestines / cytology* Stem Cells / metabolism* |
| IF | 6.032 |
| 引用数 | 20 |
| WOS 分野 | CELL & TISSUE ENGINEERING CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111803 DGRC#111763 |