Reference - Detail
| RRC ID | 32580 |
|---|---|
| Author | Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T. |
| Title | Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. |
| Journal | Immunity |
| Abstract |
We found that Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch for binding to a DNA binding protein RBP-J and suppressed the transactivation activity of Notch signaling. Although MINT null mutant mice were embryonic lethal, MINT-deficient splenic B cells differentiated about three times more efficiently into marginal zone B cells with a concomitant reduction of follicular B cells. MINT is expressed in a cell-specific manner: high in follicular B cells and low in marginal zone B cells. Since Notch signaling directs differentiation of marginal zone B lymphocytes and suppresses that of follicular B lymphocytes in mouse spleen, the results indicate that high levels of MINT negatively regulate Notch signaling and block differentiation of precursor B cells into marginal zone B cells. MINT may serve as a functional homolog of Drosophila Hairless. |
| Volume | 18(2) |
| Pages | 301-12 |
| Published | 2003-2-1 |
| DOI | 10.1016/s1074-7613(03)00029-3 |
| PII | S1074-7613(03)00029-3 |
| PMID | 12594956 |
| MeSH | Animals B-Lymphocyte Subsets / cytology B-Lymphocyte Subsets / metabolism B-Lymphocytes / cytology* B-Lymphocytes / metabolism* Cell Adhesion Molecules Cell Differentiation DNA-Binding Proteins / metabolism Drosophila Drosophila Proteins Gene Targeting Immunoglobulin J Recombination Signal Sequence-Binding Protein Liver / cytology Liver / embryology Membrane Proteins / metabolism* Mice Mice, Knockout Nuclear Proteins / deficiency Nuclear Proteins / genetics Nuclear Proteins / metabolism* Protein Binding RNA-Binding Proteins Receptors, Notch Signal Transduction Transcriptional Activation |
| IF | 22.553 |
| Times Cited | 192 |
| WOS Category | IMMUNOLOGY |
| Resource | |
| DNA material | pEF-BOSneo-Myc-MINT (1-3576)-FLAG (RDB06777) pEF-BOSneo-Myc-MINT deltaRAM7-FLAG (RDB13472) pEF-BOSneo-Myc-MINT deltaN (RDB13473) pEF-BOSneo-Myc-MINT deltaN-NLS (RDB13474) pEF-BOSneo-Myc-MINT deltaN-NLS-deltaRAM7 (RDB13475) pEF-BOSneo-Myc-MINT deltaC (RDB13476) pEF-BOSneo-MINT RAM7-Myc (RDB13477) pEF-BOSneo-MINT RAM7-VP16-Myc (RDB13478). |