RRC ID 32612
著者 Sano A, Miyaji M, Nishimura K, de Franco MF.
タイトル Studies on the relationship between the pathogenicity of Paracoccidioides brasiliensis in mice and its growth rate under different oxygen atmospheres.
ジャーナル Mycopathologia
Abstract We performed comparative studies of the pathogenicity of six strains of Paracoccidioides brasiliensis (Bt-9, Bt-4, Pb-9, Pb-18, Bt-7 and B-1183) for young adult male ddY mice and the growth rate of each strain under different oxygen atmospheres (aerobic, micro-aerobic and anaerobic atmospheres) at 37 degrees C. 10(6) units of yeast cells were intravenously injected into each mouse. The pathogenicity of each isolate was determined by a scoring system based on organ culture and histopathological findings. The growth rates under different oxygen atmospheres were determined by a scoring system in which 300 fungal units per strain were counted. The strain Bt-9 showed the greatest pathogenicity, followed by Bt-4, Pb-9 and Pb-18 had on intermediate rank of pathogenicity. Bt-7 and B-1183 were the least pathogenic of the strains tested. Except for strain Bt-7 all strains showed an excellent growth under an aerobic atmosphere. Bt-4 and Bt-9 also showed excellent growth under a micro-aerobic atmosphere, followed by Pb-9, whereas the growth of Pb-18, Bt-7 and B-1183 was limited. There was a correlation between the growth rate under a micro-aerobic atmosphere and the pathogenicity of a strain. The growth rate of P. brasiliensis under a micro-aerobic atmosphere strongly correlated to its pathogenicity.
巻・号 114(2)
ページ 93-101
公開日 1991-5-1
DOI 10.1007/BF00436428
PMID 1831538
MeSH Aerobiosis Anaerobiosis Animals Brain / microbiology Brain / pathology Heart / microbiology Kidney / microbiology Kidney / pathology Liver / microbiology Liver / pathology Lung / microbiology Lung / pathology Male Mice Myocardium / pathology Organ Culture Techniques Oxygen / metabolism* Paracoccidioides / growth & development Paracoccidioides / pathogenicity* Paracoccidioidomycosis / microbiology* Paracoccidioidomycosis / pathology Regression Analysis Specific Pathogen-Free Organisms Spleen / microbiology Spleen / pathology Virulence
IF 2.452
引用数 8
WOS 分野 MYCOLOGY
リソース情報
病原微生物 IFM 41620 IFM 41621 IFM 41624 IFM 41625 IFM 41626 IFM 41628