論文 - 詳細
| RRC ID | 32684 |
|---|---|
| 著者 | Grabher C, Cliffe A, Miura K, Hayflick J, Pepperkok R, Rørth P, Wittbrodt J. |
| タイトル | Birth and life of tissue macrophages and their migration in embryogenesis and inflammation in medaka. |
| ジャーナル | J Leukoc Biol |
| Abstract |
Macrophages detecting and migrating toward sites of injury and infection represent one of the first steps in an immune response. Here we directly image macrophage birth and migration in vivo in transgenic medaka fish. Macrophages are born as frequently dividing, immotile cells with spherical morphology that differentiate into flat, highly motile cells. They retain mitotic activity while spreading over the entire body. Cells follow restricted paths not only in directed migration, but also during patrolling. Along those paths the macrophages rapidly patrol the tissue and respond to wounding and bacterial infection from long distances. Upon injury they increase their speed and migratory persistence. Specifically targeting PI3-kinase isoforms efficiently blocks the wounding response and results in a distinct inhibition of cell motility and chemotaxis. Our study provides in situ insights into the properties of immature and migratory macrophages and presents a unique model to further test modulating compounds in vivo. |
| 巻・号 | 81(1) |
| ページ | 263-71 |
| 公開日 | 2007-1-1 |
| DOI | 10.1189/jlb.0806526 |
| PII | jlb.0806526 |
| PMID | 17046968 |
| MeSH | Animals Animals, Genetically Modified Chemotaxis* Embryonic Development / physiology* Inflammation / metabolism* Leukocytes / metabolism Macrophages / physiology* Oryzias / immunology* Phosphatidylinositol 3-Kinases / metabolism Signal Transduction |
| IF | 3.757 |
| 引用数 | 33 |
| WOS 分野 | IMMUNOLOGY HEMATOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | TG(FmpoP::EB3-EGFP/FmpoP::RFP-Lifeact) (TG1043) TG(FmpoP::mCherry) (TG1044) |