| RRC ID |
32736
|
| 著者 |
Taguchi H, Tanaka R, Miyaji M, Nishimura K, Kanno H, Ishiyama H.
|
| タイトル |
[Studies on the effect of combination of amphotericin B and flucytosine on Candida albicans by flow cytometry].
|
| ジャーナル |
Kansenshogaku Zasshi
|
| Abstract |
The antifungal effects of amphotericin B (AMPH) and flucytosine (5-FC) on three strains of Candida albicans were studied by flow cytometry (FCM). When the IFM4954 and IFM4949 were treated with AMPH or 5-FC alone, cytograms of cell distribution changed at the concentration of 1/2 MIC, respectively. Next, the effect of combination of AMPH and 5-FC were examined. Cytogram of cell distribution of IFM4954 and IFM4949 changed under the combination of 1/4 MIC of AMPH and 1/4 MIC of 5-FC, namely a synergic effect was observed. In conclusion, FCM is a useful apparatus for analysis of the effect of antifungal agents.
|
| 巻・号 |
66(4)
|
| ページ |
516-21
|
| 公開日 |
1992-4-1
|
| DOI |
10.11150/kansenshogakuzasshi1970.66.516
|
| PMID |
1624846
|
| MeSH |
Amphotericin B / pharmacology*
Candida albicans / drug effects*
Drug Therapy, Combination
Flow Cytometry
Flucytosine / pharmacology*
Methods
|
| リソース情報 |
| 病原微生物 |
IFM 4949
IFM 4954
IFM 4956 |
