RRC ID 32788
Author Kamei K, Watanabe A, Nishimura K, Miyaji M.
Title [Culture filtrate of Aspergillus fumigatus and its cytotoxic activity against leukocytes].
Journal Nihon Ishinkin Gakkai Zasshi
Abstract Aspergillosis has become the biggest cause of death among mycoses in Japan. The main causative agent is Aspergillus fumigatus and its virulence factors have been variously investigated, yet much remains to be clarified. We recently found that the culture filtrate of A. fumigatus has potent anti-leukocyte activity. It seriously damages macrophages and hampers the function of polymorphonuclear neutrophils. The filtrate is also active in vivo: when injected intraperitoneally, the culture filtrate lowered the survival of mice infected with A. fumigatus. This activity becomes overt within 24 hours of culture of the fungus. Although the mechanism of pathogenicity of A. fumigatus is believed to be somewhat complex, we suggest the activities shown in the culture filtrate may play a crucial role in the development of the infection.
Volume 43(3)
Pages 163-6
Published 2002
PMID 12145631
MeSH Animals Aspergillus fumigatus / metabolism Aspergillus fumigatus / pathogenicity* Cells, Cultured Culture Media / chemistry Humans Leukocytes / drug effects* Leukocytes / pathology Macrophages, Peritoneal / drug effects Macrophages, Peritoneal / pathology Mice Mycotoxins / biosynthesis Mycotoxins / toxicity* Neutrophils / drug effects Neutrophils / pathology Virulence Virulence Factors / biosynthesis Virulence Factors / toxicity*
Pathogenic microorganisms IFM 47047 IFM 47127 IFM 47130 IFM 47277 IFM 47439 IFM 47450 IFM 47753 IFM 47800 IFM 49437