Reference - Detail
| RRC ID | 32843 |
|---|---|
| Author | Takei T, Seki K. |
| Title | Spinal premotor interneurons mediate dynamic and static motor commands for precision grip in monkeys. |
| Journal | J Neurosci |
| Abstract |
The extent of spinal interneuron (IN) contribution to dexterous hand movements is unclear. Here, we studied the response patterns and force relationships of spinal premotor INs (PreM-INs) in three awake, behaving monkeys performing a precision grip task. We recorded activity from the cervical spinal cord (C5-T1) simultaneously with electromyographic (EMG) activity from hand and arm muscles during the task. Spike-triggered averaging of EMGs showed that 25 PreM-INs had postspike effects on EMG activity. Most PreM-INs (23/25) displayed movement-related firing rate modulations: 11 had phasic followed by tonic facilitation (p+t+); 4 were pure phasic; 4 were pure tonic; and 4 were deactivated, while their target muscles consistently had p+t+ activity (65/66 muscles). PreM-IN phasic activity started earlier than target muscle activity (49 ± 81.4 ms, mean ± SD), and the peak amplitude was correlated with the peak amplitude of the rate of change of grip force (4/17, p < 0.05), suggesting that they contributed to force initiation. In contrast, PreM-IN tonic activity started at almost the same time as the target muscle activity and the mean firing rate was correlated with the mean grip force during the hold period (4/15, p < 0.05), suggesting that they contributed to force maintenance. These results indicated that the neural pathway mediated by the spinal PreM-INs makes a significant contribution to the control of precision grip in primates. |
| Volume | 33(20) |
| Pages | 8850-60 |
| Published | 2013-5-15 |
| DOI | 10.1523/JNEUROSCI.4032-12.2013 |
| PII | 33/20/8850 |
| PMID | 23678127 |
| PMC | PMC6618822 |
| MeSH | Action Potentials / physiology Animals Electromyography Hand / physiology Hand Strength / physiology* Interneurons / physiology* Macaca fascicularis Macaca mulatta Male Motor Neurons / physiology Movement / physiology* Muscle, Skeletal / physiology Reaction Time / physiology Spinal Cord / cytology* Statistics as Topic |
| IF | 5.674 |
| Times Cited | 26 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |