Reference - Detail
| RRC ID | 33019 |
|---|---|
| Author | Williams DW, Kondo S, Krzyzanowska A, Hiromi Y, Truman JW. |
| Title | Local caspase activity directs engulfment of dendrites during pruning. |
| Journal | Nat Neurosci |
| Abstract |
Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons. |
| Volume | 9(10) |
| Pages | 1234-6 |
| Published | 2006-10-1 |
| DOI | 10.1038/nn1774 |
| PII | nn1774 |
| PMID | 16980964 |
| MeSH | Analysis of Variance Animals Animals, Genetically Modified Apoptosis Caspases / genetics Caspases / metabolism* Dendrites / enzymology* Dendrites / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Enzyme Activation / physiology Enzyme Inhibitors / pharmacology Fluorescent Antibody Technique / methods Ganglia, Spinal / cytology Neurons, Afferent / cytology* Time Factors |
| IF | 20.071 |
| Times Cited | 219 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| Drosophila | |