論文 - 詳細
| RRC ID | 33037 |
|---|---|
| 著者 | JayaNandanan N, Mathew R, Leptin M. |
| タイトル | Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin. |
| ジャーナル | Nat Commun |
| Abstract |
Apical membranes in many polarized epithelial cells show specialized morphological adaptations that fulfil distinct physiological functions. The air-transporting tubules of Drosophila tracheal terminal cells represent an extreme case of membrane specialization. Here we show that Bitesize (Btsz), a synaptotagmin-like protein family member, is needed for luminal membrane morphogenesis. Unlike in multicellular tubes and other epithelia, where it influences apical integrity by affecting adherens junctions, Btsz here acts at a distance from junctions. Localized at the luminal membrane through its tandem C2 domain, it recruits activated Moesin. Both proteins are needed for the integrity of the actin cytoskeleton at the luminal membrane, but not for other pools of F-actin in the cell, nor do actin-dependent processes at the outer membrane, such as filopodial activity or membrane growth depend on Btsz. Btsz and Moesin guide luminal membrane morphogenesis through organizing actin and allowing the incorporation of membrane containing the apical determinant Crumbs. |
| 巻・号 | 5 |
| ページ | 3036 |
| 公開日 | 2014-1-13 |
| DOI | 10.1038/ncomms4036 |
| PII | ncomms4036 |
| PMID | 24413568 |
| PMC | PMC3945880 |
| MeSH | Actins / physiology* Animals Cells, Cultured Cytoskeleton / physiology* Drosophila / physiology* Drosophila Proteins / physiology* Epithelial Cells / cytology Epithelial Cells / physiology Intercellular Junctions / physiology Membrane Proteins / physiology* Morphogenesis / physiology Trachea / cytology Trachea / physiology |
| IF | 12.121 |
| 引用数 | 18 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | 7343R-1 10701R-1 |