論文 - 詳細
| RRC ID | 33046 |
|---|---|
| 著者 | Hong W, Mosca TJ, Luo L. |
| タイトル | Teneurins instruct synaptic partner matching in an olfactory map. |
| ジャーナル | Nature |
| Abstract |
Neurons are interconnected with extraordinary precision to assemble a functional nervous system. Compared to axon guidance, far less is understood about how individual pre- and postsynaptic partners are matched. To ensure the proper relay of olfactory information in the fruitfly Drosophila, axons of ∼50 classes of olfactory receptor neurons (ORNs) form one-to-one connections with dendrites of ∼50 classes of projection neurons (PNs). Here, using genetic screens, we identified two evolutionarily conserved, epidermal growth factor (EGF)-repeat containing transmembrane Teneurin proteins, Ten-m and Ten-a, as synaptic-partner-matching molecules between PN dendrites and ORN axons. Ten-m and Ten-a are highly expressed in select PN-ORN matching pairs. Teneurin loss- and gain-of-function cause specific mismatching of select ORNs and PNs. Finally, Teneurins promote homophilic interactions in vitro, and Ten-m co-expression in non-partner PNs and ORNs promotes their ectopic connections in vivo. We propose that Teneurins instruct matching specificity between synaptic partners through homophilic attraction. |
| 巻・号 | 484(7393) |
| ページ | 201-7 |
| 公開日 | 2012-3-18 |
| DOI | 10.1038/nature10926 |
| PII | nature10926 |
| PMID | 22425994 |
| PMC | PMC3345284 |
| MeSH | Animals Axons / metabolism Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Olfactory Pathways / physiology* Olfactory Receptor Neurons / metabolism Protein Binding RNA Interference Receptors, Cell Surface / metabolism* Smell / physiology Synapses / metabolism* Tenascin / metabolism* |
| IF | 42.779 |
| 引用数 | 120 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 5723R-1 2590R-1 2590R-2 |