論文 - 詳細
| RRC ID | 33060 |
|---|---|
| 著者 | Shim J, Mukherjee T, Mondal BC, Liu T, Young GC, Wijewarnasuriya DP, Banerjee U. |
| タイトル | Olfactory control of blood progenitor maintenance. |
| ジャーナル | Cell |
| Abstract |
Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP: |
| 巻・号 | 155(5) |
| ページ | 1141-53 |
| 公開日 | 2013-11-21 |
| DOI | 10.1016/j.cell.2013.10.032 |
| PII | S0092-8674(13)01350-0 |
| PMID | 24267893 |
| PMC | PMC3865989 |
| MeSH | Animals Drosophila melanogaster / cytology* Drosophila melanogaster / physiology* Hemolymph / cytology* Lymphoid Tissue / cytology Neurons / metabolism Olfactory Perception Olfactory Receptor Neurons / metabolism Signal Transduction Stem Cells / cytology* Stem Cells / metabolism gamma-Aminobutyric Acid / metabolism |
| IF | 38.637 |
| 引用数 | 50 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |