論文 - 詳細
| RRC ID | 33127 |
|---|---|
| 著者 | Edayoshi M, Yamaguchi J, Fujiwara H. |
| タイトル | Protruding structures on caterpillars are controlled by ectopic Wnt1 expression. |
| ジャーナル | PLoS One |
| Abstract |
Spine-like or protruding structures, which may be aposematic for predators, are often observed in multiple segments of lepidopteran larvae (caterpillars). For example, the larvae of the Chinese wheel butterfly, Byasa alcinous, display many protrusions on their backs as a warning that they are toxic. Although these protrusions are formed by an integument lined with single-layered epidermal cells, the molecular mechanisms underlying their formation have remained unclear. In this study, we focused on a spontaneous mutant of the silkworm, Bombyx mori, Knobbed, which shows similar protrusions to B. alcinous and demonstrates that Wnt1 plays a crucial role in the formation of protrusion structures. Using both transgene expression and RNAi-based knockdown approaches, we showed that Wnt1 designates the position where epidermal cells excessively proliferate, leading to the generation of knobbed structures. Furthermore, in the B. alcinous larvae, Wnt1 was also specifically expressed in association with the protrusions. Our results suggest that Wnt1 plays a role in the formation of protrusions on the larval body, and is conserved broadly among diverse species in Lepidoptera. |
| 巻・号 | 10(3) |
| ページ | e0121736 |
| 公開日 | 2015-1-1 |
| DOI | 10.1371/journal.pone.0121736 |
| PII | PONE-D-14-28290 |
| PMID | 25815728 |
| PMC | PMC4376876 |
| MeSH | Animals Bombyx / anatomy & histology Bombyx / genetics* Bombyx / growth & development Bombyx / metabolism Conserved Sequence Insect Proteins / genetics Insect Proteins / metabolism* Integumentary System / growth & development Larva / anatomy & histology Larva / genetics Larva / metabolism Wnt1 Protein / genetics Wnt1 Protein / metabolism* |
| IF | 2.74 |
| 引用数 | 3 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | n51 g01 f39 |