RRC ID 33130
著者 Fujiwara T, Kazawa T, Sakurai T, Fukushima R, Uchino K, Yamagata T, Namiki S, Haupt SS, Kanzaki R.
タイトル Odorant concentration differentiator for intermittent olfactory signals.
ジャーナル J Neurosci
Abstract Animals need to discriminate differences in spatiotemporally distributed sensory signals in terms of quality as well as quantity for generating adaptive behavior. Olfactory signals characterized by odor identity and concentration are intermittently distributed in the environment. From these intervals of stimulation, animals process odorant concentration to localize partners or food sources. Although concentration-response characteristics in olfactory neurons have traditionally been investigated using single stimulus pulses, their behavior under intermittent stimulus regimens remains largely elusive. Using the silkmoth (Bombyx mori) pheromone processing system, a simple and behaviorally well-defined model for olfaction, we investigated the neuronal representation of odorant concentration upon intermittent stimulation in the naturally occurring range. To the first stimulus in a series, the responses of antennal lobe (AL) projection neurons (PNs) showed a concentration dependence as previously shown in many olfactory systems. However, PN response amplitudes dynamically changed upon exposure to intermittent stimuli of the same odorant concentration and settled to a constant, largely concentration-independent level. As a result, PN responses emphasized odorant concentration changes rather than encoding absolute concentration in pulse trains of stimuli. Olfactory receptor neurons did not contribute to this response transformation which was due to long-lasting inhibition affecting PNs in the AL. Simulations confirmed that inhibition also provides advantages when stimuli have naturalistic properties. The primary olfactory center thus functions as an odorant concentration differentiator to efficiently detect concentration changes, thereby improving odorant source orientation over a wide concentration range.
巻・号 34(50)
ページ 16581-93
公開日 2014-12-10
DOI 10.1523/JNEUROSCI.2319-14.2014
PII 34/50/16581
PMID 25505311
PMC PMC6608502
MeSH Animals Animals, Genetically Modified Bombyx Dose-Response Relationship, Drug Fatty Alcohols / pharmacology Female Male Odorants* Olfactory Pathways / drug effects Olfactory Pathways / physiology* Olfactory Receptor Neurons / drug effects Olfactory Receptor Neurons / physiology* Receptors, Odorant / physiology* Smell / drug effects Smell / physiology*
IF 5.674
引用数 11
WOS 分野 NEUROSCIENCES
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