| RRC ID |
33164
|
| 著者 |
Tavares L, Pereira E, Correia A, Santos MA, Amaral N, Martins T, Relvas JB, Pereira PS.
|
| タイトル |
Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions.
|
| ジャーナル |
Glia
|
| Abstract |
Cellular migration and differentiation are important developmental processes that require dynamic cellular adhesion. Integrins are heterodimeric transmembrane receptors that play key roles in adhesion plasticity. Here, we explore the developing visual system of Drosophila to study the roles of integrin heterodimers in glia development. Our data show that αPS2 is essential for retinal glia migration from the brain into the eye disc and that glial cells have a role in the maintenance of the fenestrated membrane (Laminin-rich ECM layer) in the disc. Interestingly, the absence of glial cells in the eye disc did not affect the targeting of retinal axons to the optic stalk. In contrast, αPS3 is not required for retinal glia migration, but together with Talin, it functions in glial cells to allow photoreceptor axons to target the optic stalk. Thus, we present evidence that αPS2 and αPS3 integrin have different and specific functions in the development of retinal glia.
|
| 巻・号 |
63(7)
|
| ページ |
1155-65
|
| 公開日 |
2015-7-1
|
| DOI |
10.1002/glia.22806
|
| PMID |
25731761
|
| MeSH |
Animals
Animals, Genetically Modified
Axons / physiology
Cell Communication / physiology*
Drosophila
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Immunohistochemistry
Integrin alpha Chains / genetics
Integrin alpha Chains / metabolism*
Microscopy, Electron, Transmission
Neuroglia / physiology*
Photoreceptor Cells, Vertebrate / physiology*
RNA Interference
Talin / metabolism
|
| IF |
5.984
|
| 引用数 |
9
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
|
