RRC ID 33168
著者 Okabe F, Nakagiri Y, Yamada T, Kose H.
タイトル Laser induced injury caused hyperglycemia-like effect in Drosophila larva: a possible insect model for posttraumatic diabetes.
ジャーナル J Vet Med Sci
Abstract Diabetic patients need particular care in case of infection, digestive disorder or external injury, because external stress often exasperates the glucose metabolism, which is known as "sick day management". In addition, severe trauma can be a cause of hyperglycemia with insulin resistance. In spite of critical component of the treatment, the precise mechanisms of how trauma develops posttraumatic diabetes remain unknown. Here, we ablated body wall muscles in Drosophila larvae by laser beam and found that the level of trehalose, the principal sugar circulating in the hemolymph or in the tissues of most insects, was increased. The model may provide a helpful tool to understand the relationship between trauma and sugar metabolism.
巻・号 77(5)
ページ 601-4
公開日 2015-5-1
DOI 10.1292/jvms.14-0631
PMID 25649060
PMC PMC4478742
MeSH Animals Disease Models, Animal* Drosophila / metabolism* Drosophila / radiation effects* Glucose / metabolism* Larva / metabolism Larva / radiation effects Lasers*
IF 1.049
引用数 1
WOS 分野 VETERINARY SCIENCES
リソース情報
ショウジョウバエ 5053A-Gal4 (DGRC#107443) NP6310 (DGRC#113906)