論文 - 詳細
| RRC ID | 33168 |
|---|---|
| 著者 | Okabe F, Nakagiri Y, Yamada T, Kose H. |
| タイトル | Laser induced injury caused hyperglycemia-like effect in Drosophila larva: a possible insect model for posttraumatic diabetes. |
| ジャーナル | J Vet Med Sci |
| Abstract |
Diabetic patients need particular care in case of infection, digestive disorder or external injury, because external stress often exasperates the glucose metabolism, which is known as "sick day management". In addition, severe trauma can be a cause of hyperglycemia with insulin resistance. In spite of critical component of the treatment, the precise mechanisms of how trauma develops posttraumatic diabetes remain unknown. Here, we ablated body wall muscles in Drosophila larvae by laser beam and found that the level of trehalose, the principal sugar circulating in the hemolymph or in the tissues of most insects, was increased. The model may provide a helpful tool to understand the relationship between trauma and sugar metabolism. |
| 巻・号 | 77(5) |
| ページ | 601-4 |
| 公開日 | 2015-5-1 |
| DOI | 10.1292/jvms.14-0631 |
| PMID | 25649060 |
| PMC | PMC4478742 |
| MeSH | Animals Disease Models, Animal* Drosophila / metabolism* Drosophila / radiation effects* Glucose / metabolism* Larva / metabolism Larva / radiation effects Lasers* |
| IF | 1.049 |
| 引用数 | 1 |
| WOS 分野 | VETERINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | 5053A-Gal4 (DGRC#107443) NP6310 (DGRC#113906) |