RRC ID 33226
Author Ge W, Chen YW, Weng R, Lim SF, Buescher M, Zhang R, Cohen SM.
Title Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
Journal Cell Death Differ.
Abstract Regulation of apoptosis is crucial for tissue homeostasis under normal development and environmental stress. In Drosophila, cell death occurs in different developmental processes including embryogenesis. Here, we report that two members of the miR-2 seed family of microRNAs, miR-6 and miR-11, function together to limit the level of apoptosis during Drosophila embryonic development. Mutants lacking both miR-6 and miR-11 show embryonic lethality and defects in the central nervous system (CNS). We provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl). Upregulation of these proapoptotic genes is responsible for the elevated apoptosis and the CNS defects in the mutants. These findings demonstrate that the activity of the proapoptotic genes is kept in check by miR-6/11 to ensure normal development.
Volume 19(5)
Pages 839-46
Published 2012-5
DOI 10.1038/cdd.2011.161
PII cdd2011161
PMID 22095284
PMC PMC3321623
MeSH Animals Animals, Genetically Modified Apoptosis / genetics Apoptosis / physiology* Central Nervous System / embryology Central Nervous System / metabolism Drosophila / embryology* Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Embryonic Development / genetics Embryonic Development / physiology* MicroRNAs / genetics* MicroRNAs / metabolism Neuropeptides / genetics Neuropeptides / metabolism
IF 8.086
Times Cited 22