論文 - 詳細
| RRC ID | 3328 |
|---|---|
| 著者 | Ogawa T, Murakami K, Mori H, Ishii N, Tomita M, Yoshin M. |
| タイトル | Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli. |
| ジャーナル | J Bacteriol |
| Abstract |
Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (Ki of 0.31 mM) and isocitrate lyase uncompetitively (Ki' of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt. |
| 巻・号 | 189(3) |
| ページ | 1176-8 |
| 公開日 | 2007-2-1 |
| DOI | 10.1128/JB.01628-06 |
| PII | JB.01628-06 |
| PMID | 17142397 |
| PMC | PMC1797289 |
| MeSH | Escherichia coli / drug effects Escherichia coli / enzymology Escherichia coli / metabolism* Isocitrate Dehydrogenase / antagonists & inhibitors Isocitrate Dehydrogenase / metabolism* Isocitrate Lyase / antagonists & inhibitors Isocitrate Lyase / metabolism* Isocitrates / metabolism Isocitrates / pharmacology Kinetics NADP / metabolism Phosphoenolpyruvate / metabolism* Phosphoenolpyruvate / pharmacology |
| IF | 3.006 |
| 引用数 | 13 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| 原核生物(大腸菌) | ? W3110 |