論文 - 詳細
| RRC ID | 33303 |
|---|---|
| 著者 | Matsunaga E, Nambu S, Oka M, Tanaka M, Taoka M, Iriki A. |
| タイトル | Periostin, a neurite outgrowth-promoting factor, is expressed at high levels in the primate cerebral cortex. |
| ジャーナル | Dev Growth Differ |
| Abstract |
Periostin (POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative gene expression analysis of periostin between rodents (mice) and primates (marmosets and macaques). Periostin was expressed at higher levels in the primate cerebral cortex compared to the mouse cerebral cortex. Furthermore, we performed overexpression experiments of periostin in vivo and in vitro. Periostin exhibited neurite outgrowth activity in cortical neurons. These results suggested the possibility that prolonged and increased periostin expression in the primate cerebral cortex enhances the cortical plasticity of the mammalian cerebral cortex. |
| 巻・号 | 57(3) |
| ページ | 200-8 |
| 公開日 | 2015-4-1 |
| DOI | 10.1111/dgd.12194 |
| PMID | 25703431 |
| MeSH | Animals Callithrix / metabolism* Cell Adhesion Molecules / metabolism* Cerebral Cortex / cytology Cerebral Cortex / metabolism* DNA Primers / genetics Hippocampus / cytology Immunohistochemistry In Situ Hybridization Macaca / metabolism* Mice Neurites / metabolism* Neuronal Plasticity / physiology* Plasmids / genetics Rats Species Specificity |
| IF | 1.723 |
| 引用数 | 10 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |