| RRC ID |
33359
|
| 著者 |
Hosoya T, Takizawa K, Nitta K, Hotta Y.
|
| タイトル |
glial cells missing: a binary switch between neuronal and glial determination in Drosophila.
|
| ジャーナル |
Cell
|
| Abstract |
In the Drosophila CNS, both neurons and glial are derived from neuroblasts. We have identified a gene, glial cells missing (gcm), that encodes a novel nuclear protein expressed transiently in early glial cells. Its mutation causes presumptive glial cells to differentiate into neurons, whereas its ectopic expression forces virtually all CNS cells to become glial cells. Thus, gcm functions as a binary switch that turns on glial fate while inhibiting default neuronal fate of the neuroblasts and their progeny. Similar results are also obtained in the PNS. Analyses of the mutant revealed that "pioneer neurons" can find correct pathways without glial cells and that neurons and glia have a common molecular basis for individual identity.
|
| 巻・号 |
82(6)
|
| ページ |
1025-36
|
| 公開日 |
1995-9-22
|
| DOI |
10.1016/0092-8674(95)90281-3
|
| PII |
0092-8674(95)90281-3
|
| PMID |
7553844
|
| MeSH |
Amino Acid Sequence
Animals
Cell Differentiation / genetics
Cell Movement / genetics
Central Nervous System / cytology
Central Nervous System / embryology
Drosophila / genetics*
Gene Expression Regulation, Developmental / physiology
Genes, Insect / physiology
Molecular Sequence Data
Mutation / genetics
Neuroglia / physiology*
Neurons / physiology*
Nuclear Proteins / genetics
Peripheral Nervous System / cytology
Peripheral Nervous System / embryology
|
| IF |
38.637
|
| 引用数 |
353
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
|
