Reference - Detail
RRC ID | 3338 |
---|---|
Author | Takeda O, Takechi S, Ito S, Omori H, Katoh T, Yamaguchi T. |
Title | Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli. |
Journal | Biol Pharm Bull |
Abstract |
Phenyl-substituted dihydropyrazines (Ph-DHPs) are derivatives of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP). Upon the addition of Cu(2+), Me-DHP inhibits the growth of Escherichia coli by generating hydroxyl and carbon-centered radicals that cause DNA strand breakage. Here, we investigated the toxic effect of Ph-DHPs in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains. Ph-DHPs caused cytotoxic and genotoxic damage, but, in a sodA sodB strain, the effects in the presence or absence of Cu(2+) were different than those of Me-DHP. Our results suggest that the action of the generated superoxide anion in the interior side of the cell is remarkable. |
Volume | 30(9) |
Pages | 1663-7 |
Published | 2007-9-1 |
DOI | 10.1248/bpb.30.1663 |
PII | JST.JSTAGE/bpb/30.1663 |
PMID | 17827717 |
MeSH | Aminolevulinic Acid / metabolism Copper / pharmacology DNA / drug effects DNA / genetics DNA Repair / drug effects Electron Spin Resonance Spectroscopy Escherichia coli K12 / drug effects Escherichia coli K12 / genetics Escherichia coli K12 / metabolism* Liver Neoplasms / chemically induced Liver Neoplasms / pathology Mutation Phenyl Ethers / chemistry Phenyl Ethers / metabolism Pyrazines / chemistry Pyrazines / pharmacology* Tetrazolium Salts / metabolism |
IF | 1.863 |
Times Cited | 14 |
WOS Category | PHARMACOLOGY & PHARMACY |
Resource | |
Prokaryotes E. coli | ME8079(AB1157) ME8087(AB2463) ME8080(AB1885) |