RRC ID 335
Author Sawamura K, Roote J, Wu CI, Yamamoto MT.
Title Genetic complexity underlying hybrid male sterility in Drosophila.
Journal Genetics
Abstract Recent genetic analyses of closely related species of Drosophila have indicated that hybrid male sterility is the consequence of highly complex synergistic effects among multiple genes, both conspecific and heterospecific. On the contrary, much evidence suggests the presence of major genes causing hybrid female sterility and inviability in the less-related species, D. melanogaster and D. simulans. Does this contrast reflect the genetic distance between species? Or, generally, is the genetic basis of hybrid male sterility more complex than that of hybrid female sterility and inviability? To clarify this point, the D. simulans introgression of the cytological region 34D-36A to the D. melanogaster genome, which causes recessive male sterility, was dissected by recombination, deficiency, and complementation mapping. The 450-kb region between two genes, Suppressor of Hairless and snail, exhibited a strong effect on the sterility. Males are (semi-)sterile if this region of the introgression is made homozygous or hemizygous. But no genes in the region singly cause the sterility; this region has at least two genes, which in combination result in male sterility. Further, the males are less fertile when heterozygous with a larger introgression, which suggests that dominant modifiers enhance the effects of recessive genes of male sterility. Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility.
Volume 166(2)
Pages 789-96
Published 2004-2-1
DOI 10.1534/genetics.166.2.789
PII 166/2/789
PMID 15020468
PMC PMC1470755
MeSH Alcohol Dehydrogenase / genetics Animals Chromosome Mapping Drosophila melanogaster / genetics* Female Genetic Markers Heterozygote Hybridization, Genetic* Infertility, Male / genetics* Male Mutation Sequence Analysis, DNA
IF 4.015
Times Cited 25