RRC ID 33521
著者 Artyukhin AB, Yim JJ, Cheong Cheong M, Avery L.
タイトル Starvation-induced collective behavior in C. elegans.
ジャーナル Sci Rep
Abstract We describe a new type of collective behavior in C. elegans nematodes, aggregation of starved L1 larvae. Shortly after hatching in the absence of food, L1 larvae arrest their development and disperse in search for food. In contrast, after two or more days without food, the worms change their behavior--they start to aggregate. The aggregation requires a small amount of ethanol or acetate in the environment. In the case of ethanol, it has to be metabolized, which requires functional alcohol dehydrogenase sodh-1. The resulting acetate is used in de novo fatty acid synthesis, and some of the newly made fatty acids are then derivatized to glycerophosphoethanolamides and released into the surrounding medium. We examined several other Caenorhabditis species and found an apparent correlation between propensity of starved L1s to aggregate and density dependence of their survival in starvation. Aggregation locally concentrates worms and may help the larvae to survive long starvation. This work demonstrates how presence of ethanol or acetate, relatively abundant small molecules in the environment, induces collective behavior in C. elegans associated with different survival strategies.
巻・号 5
ページ 10647
公開日 2015-5-27
DOI 10.1038/srep10647
PII srep10647
PMID 26013573
PMC PMC4445038
MeSH Acetates / metabolism Alcohol Dehydrogenase / metabolism Animals Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Ethanol / metabolism Fatty Acids / biosynthesis Larva / metabolism Starvation*
IF 3.998
引用数 12
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 sodh-1 (tm2829)