RRC ID 33539
Author Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL.
Title Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.
Journal J. Bacteriol.
Abstract Additional targets of CodY, a GTP-activated repressor of early stationary-phase genes in Bacillus subtilis, were identified by combining chromatin immunoprecipitation, DNA microarray hybridization, and gel mobility shift assays. The direct targets of CodY newly identified by this approach included regulatory genes for sporulation, genes that are likely to encode transporters for amino acids and sugars, and the genes for biosynthesis of branched-chain amino acids.
Volume 185(6)
Pages 1911-22
Published 2003-3
PMID 12618455
PMC PMC150151
MeSH Bacillus subtilis / genetics Bacillus subtilis / growth & development Bacillus subtilis / metabolism* Bacterial Proteins / genetics Bacterial Proteins / metabolism* Chromatin DNA, Bacterial / metabolism DNA-Binding Proteins* Gene Expression Regulation, Bacterial* Lac Operon / genetics Mutation Oligonucleotide Array Sequence Analysis / methods* Precipitin Tests / methods* Promoter Regions, Genetic Recombinant Fusion Proteins Repressor Proteins / genetics Repressor Proteins / metabolism* Transcription, Genetic
IF 3.219
Times Cited 186
Prokaryotes B. subtilis MBS239 MBS218 MBS219 MBS230 MBS231 MBS232 MBS233 MBS234 MBS235 MBS236 MBS237 MBS238 MBS240 MBS242