論文 - 詳細
| RRC ID | 33661 |
|---|---|
| 著者 | Pistocchi A, Gaudenzi G, Foglia E, Monteverde S, Moreno-Fortuny A, Pianca A, Cossu G, Cotelli F, Messina G. |
| タイトル | Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution. |
| ジャーナル | Development |
| Abstract |
During mouse skeletal muscle development, the Nfix gene has a pivotal role in regulating fetal-specific transcription. Zebrafish and mice share related programs for muscle development, although zebrafish develops at a much faster rate. In fact, although mouse fetal muscle fibers form after 15 days of development, in fish secondary muscle fibers form by 48 hours post-fertilization in a process that until now has been poorly characterized mechanically. In this work, we studied the zebrafish ortholog Nfix (nfixa) and its role in the proper switch to the secondary myogenic wave. This allowed us to highlight evolutionarily conserved and divergent functions of Nfix. In fact, the knock down of nfixa in zebrafish blocks secondary myogenesis, as in mouse, but also alters primary slow muscle fiber formation. Moreover, whereas Nfix mutant mice are motile, nfixa knockdown zebrafish display impaired motility that probably depends upon disruption of the sarcoplasmic reticulum. We conclude that, during vertebrate evolution, the transcription factor Nfix lost some specific functions, probably as a consequence of the different environment in which teleosts and mammals develop. |
| 巻・号 | 140(7) |
| ページ | 1528-36 |
| 公開日 | 2013-4-1 |
| DOI | 10.1242/dev.076315 |
| PII | 140/7/1528 |
| PMID | 23482488 |
| MeSH | Animals Animals, Genetically Modified Conserved Sequence / physiology Embryo, Mammalian Embryo, Nonmammalian Evolution, Molecular* Genetic Speciation Mice Muscle Development / genetics Muscle Development / physiology Muscle, Skeletal / embryology* Muscle, Skeletal / metabolism NFI Transcription Factors / genetics NFI Transcription Factors / physiology* Phylogeny Vertebrates / embryology Vertebrates / genetics* Vertebrates / physiology Zebrafish / embryology Zebrafish / genetics Zebrafish Proteins / genetics Zebrafish Proteins / physiology* |
| IF | 5.611 |
| 引用数 | 15 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(isl1:GFP)/rw0 |