論文 - 詳細
| RRC ID | 33675 |
|---|---|
| 著者 | Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K. |
| タイトル | Wnt/Dkk negative feedback regulates sensory organ size in zebrafish. |
| ジャーナル | Curr Biol |
| Abstract |
Correct organ size must involve a balance between promotion and inhibition of cell proliferation. A mathematical model has been proposed in which an organ is assumed to produce its own growth activator as well as a growth inhibitor [1], but there is as yet no molecular evidence to support this model [2]. The mechanosensory organs of the fish lateral line system (neuromasts) are composed of a core of sensory hair cells surrounded by nonsensory support cells. Sensory cells are constantly replaced and are regenerated from surrounding nonsensory cells [3], while each organ retains the same size throughout life. Moreover, neuromasts also bud off new neuromasts, which stop growing when they reach the same size [4, 5]. Here, we show that the size of neuromasts is controlled by a balance between growth-promoting Wnt signaling activity in proliferation-competent cells and Wnt-inhibiting Dkk activity produced by differentiated sensory cells. This negative feedback loop from Dkk (secreted by differentiated cells) on Wnt-dependent cell proliferation (in surrounding cells) also acts during regeneration to achieve size constancy. This study establishes Wnt/Dkk as a novel mechanism to determine the final size of an organ. |
| 巻・号 | 23(16) |
| ページ | 1559-65 |
| 公開日 | 2013-8-19 |
| DOI | 10.1016/j.cub.2013.06.035 |
| PII | S0960-9822(13)00760-4 |
| PMID | 23891113 |
| MeSH | Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / growth & development Animals, Genetically Modified / physiology Cell Differentiation Cell Proliferation Feedback Gene Expression Regulation, Developmental Intercellular Signaling Peptides and Proteins / genetics* Intercellular Signaling Peptides and Proteins / metabolism Lateral Line System / anatomy & histology Lateral Line System / growth & development* Organ Size Polymerase Chain Reaction Regeneration Wnt Signaling Pathway* Zebrafish / genetics Zebrafish / growth & development Zebrafish / physiology* Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism |
| IF | 9.601 |
| 引用数 | 40 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(6xTcf/LefBS-miniP:d2EGFP)isi01 UAS:GFP SAGFF(LF)73A krt4p:Gal4 dkk1a-RFP dkk2-RFP |