RRC ID 33713
著者 Ma X, Xu W, Zhang D, Yang Y, Li W, Xue L.
タイトル Wallenda regulates JNK-mediated cell death in Drosophila.
ジャーナル Cell Death Dis
Abstract The c-Jun N-terminal kinase (JNK) pathway plays essential roles in regulating a variety of cellular processes including proliferation, migration and survival. Previous genetic studies in Drosophila have identified numerous cell death regulating genes, providing new insights into the mechanisms for related diseases. Despite the known role of the small GTPase Rac1 in regulating cell death, the downstream components and underlying mechanism remain largely elusive. Here, we show that Rac1 promotes JNK-dependent cell death through Wallenda (Wnd). In addition, we find that Wnd triggers JNK activation and cell death via its kinase domain. Moreover, we show that both MKK4 and Hep are critical for Wnd-induced cell death. Furthermore, Wnd is essential for ectopic Egr- or Rho1-induced JNK activation and cell death. Finally, Wnd is physiologically required for loss of scribble-induced JNK-dependent cell death. Thus, our data suggest that wnd encodes a novel essential cell death regulator in Drosophila.
巻・号 6(5)
ページ e1737
公開日 2015-5-7
DOI 10.1038/cddis.2015.111
PII cddis2015111
PMID 25950467
PMC PMC4669691
MeSH Animals Apoptosis / physiology Cell Death / physiology Drosophila Drosophila Proteins / genetics* Drosophila Proteins / metabolism JNK Mitogen-Activated Protein Kinases / metabolism* MAP Kinase Kinase Kinases / genetics* MAP Kinase Kinase Kinases / metabolism
IF 6.304
引用数 13
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ 2248R-1