RRC ID 33716
著者 Luo L, Wang H, Fan C, Liu S, Cai Y.
タイトル Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche.
ジャーナル J Cell Biol
Abstract Stem cell self-renewal versus differentiation is regulated by the niche, which provides localized molecules that favor self-renewal. In the Drosophila melanogaster female germline stem cell (GSC) niche, Decapentaplegic (Dpp), a fly transforming growth factor β molecule and well-established long-range morphogen, acts over one cell diameter to maintain the GSCs. Here, we show that Thickveins (Tkv; a type I receptor of Dpp) is highly expressed in stromal cells next to Dpp-producing cells and functions to remove excess Dpp outside the niche, thereby spatially restricting its activity. Interestingly, Tkv expression in these stromal cells is regulated by multiple Wnt ligands that are produced by the niche. Our data demonstrate a self-restraining mechanism by which the Drosophila ovarian GSC niche acts to define its own boundary.
巻・号 209(4)
ページ 595-608
公開日 2015-5-25
DOI 10.1083/jcb.201409142
PII jcb.201409142
PMID 26008746
PMC PMC4442805
MeSH Animals Cell Line Cell Proliferation Drosophila / cytology Drosophila / genetics Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* ErbB Receptors / metabolism Female Gene Expression Gene Expression Regulation Germ Cells / physiology Ovary / cytology Ovary / metabolism Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Receptors, Cell Surface / genetics Receptors, Cell Surface / metabolism* Receptors, Invertebrate Peptide / metabolism Stem Cell Niche* Wnt Proteins / physiology* Wnt Signaling Pathway
IF 8.811
引用数 34
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ 11518R-1