Reference - Detail
|Author||Ji YJ, Singaravelu G, Ahnn J.|
|Title||RNT-1 regulation in C. elegans.|
|Journal||J. Cell. Biochem.|
RUNXs are important transcription factors, which are involved in animal development and human carcinogenesis. RNT-1, the only homologue of RUNXs, in Caenorhabditis elegans (C. elegans) has been identified and viable mutant animals of rnt-1 gene have been isolated and characterized recently. Genetic analyses using rnt-1 mutants have shown that RNT-1 is regulated by TGFbeta- and Wnt-signaling pathways in the body size regulation and male tail development. Here, we review our current understanding of RNT-1 functions in these signaling pathways. Furthermore, future prospects of RNT-1 and BRO-1 studies in C. elegans are discussed in this review.
|MeSH||Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Gene Expression Regulation / physiology* Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Signal Transduction / physiology Transcription Factors / genetics Transcription Factors / physiology* Transforming Growth Factor beta / physiology|
|WOS Category||BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY|