Reference - Detail
| RRC ID | 3387 |
|---|---|
| Author | Ji YJ, Singaravelu G, Ahnn J. |
| Title | RNT-1 regulation in C. elegans. |
| Journal | J Cell Biochem |
| Abstract |
RUNXs are important transcription factors, which are involved in animal development and human carcinogenesis. RNT-1, the only homologue of RUNXs, in Caenorhabditis elegans (C. elegans) has been identified and viable mutant animals of rnt-1 gene have been isolated and characterized recently. Genetic analyses using rnt-1 mutants have shown that RNT-1 is regulated by TGFbeta- and Wnt-signaling pathways in the body size regulation and male tail development. Here, we review our current understanding of RNT-1 functions in these signaling pathways. Furthermore, future prospects of RNT-1 and BRO-1 studies in C. elegans are discussed in this review. |
| Volume | 96(1) |
| Pages | 8-15 |
| Published | 2005-9-1 |
| DOI | 10.1002/jcb.20423 |
| PMID | 15988754 |
| MeSH | Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Gene Expression Regulation / physiology* Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Signal Transduction / physiology Transcription Factors / genetics Transcription Factors / physiology* Transforming Growth Factor beta / physiology |
| IF | 4.237 |
| Times Cited | 3 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm388 tm658 |