Reference - Detail
| RRC ID | 3391 |
|---|---|
| Author | Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. |
| Title | Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. |
| Journal | Genes Dev |
| Abstract |
beta-Catenin regulates cell adhesion and cellular differentiation during development, and misregulation of beta-catenin contributes to numerous forms of cancer in humans. Here we describe Caenorhabditis elegans conditional alleles of mom-2/Wnt, mom-4/Tak1, and wrm-1/beta-catenin. We use these reagents to examine the regulation of WRM-1/beta-catenin during a Wnt-signaling-induced asymmetric cell division. While WRM-1 protein initially accumulates in the nuclei of all cells, signaling promotes the retention of WRM-1 in nuclei of responding cells. We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of beta-catenin during polarized cell division. |
| Volume | 19(15) |
| Pages | 1749-54 |
| Published | 2005-8-1 |
| DOI | 10.1101/gad.1323705 |
| PII | 19/15/1749 |
| PMID | 16077004 |
| PMC | PMC1182335 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism* Cell Division Cell Nucleus / metabolism Cell Polarity Cytoskeletal Proteins / metabolism* Green Fluorescent Proteins / metabolism Intercellular Signaling Peptides and Proteins / metabolism* Membrane Proteins / chemistry Membrane Proteins / metabolism Molecular Sequence Data Sequence Homology, Amino Acid Signal Transduction* Trans-Activators / metabolism* Wnt Proteins beta Catenin |
| IF | 9.527 |
| Times Cited | 66 |
| WOS Category | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm514 |