RRC ID 3392
著者 Neves A, Priess JR.
タイトル The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways.
ジャーナル Dev Cell
Abstract Much of the patterning of early C. elegans embryos involves a series of Notch interactions that occur in rapid succession and have distinct outcomes; however, none of the targets for these interactions have been identified. We show that the REF-1 family of bHLH transcription factors is a major target of Notch signaling in all these interactions and that most examples of Notch-mediated transcriptional repression can be attributed to REF-1 activities. The REF-1 family is expressed and has similar functions in both Notch-dependent and Notch-independent pathways, and this dual mode of deployment is used repeatedly to pattern the embryo. REF-1 proteins are unusual in that they contain two different bHLH domains and lack the distinguishing characteristics of Hairy/Enhancer of Split (HES) bHLH proteins that are Notch targets in other systems. Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling.
巻・号 8(6)
ページ 867-79
公開日 2005-6-1
DOI 10.1016/j.devcel.2005.03.012
PII S1534-5807(05)00103-6
PMID 15935776
MeSH Age Factors Animals Animals, Genetically Modified Basic Helix-Loop-Helix Transcription Factors Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism* Drosophila Drosophila Proteins Embryo, Nonmammalian Fluorescent Antibody Technique / methods Gene Expression Regulation, Developmental / physiology* Membrane Proteins / physiology* Models, Biological Molecular Sequence Data Morphogenesis / physiology Mutagenesis / physiology RNA, Double-Stranded / metabolism Receptors, Notch Sequence Alignment Signal Transduction / physiology* Transcription Factors / metabolism*
IF 10.092
引用数 63
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm275 tm458 tm284