論文 - 詳細
RRC ID | 3392 |
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著者 | Neves A, Priess JR. |
タイトル | The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. |
ジャーナル | Dev Cell |
Abstract |
Much of the patterning of early C. elegans embryos involves a series of Notch interactions that occur in rapid succession and have distinct outcomes; however, none of the targets for these interactions have been identified. We show that the REF-1 family of bHLH transcription factors is a major target of Notch signaling in all these interactions and that most examples of Notch-mediated transcriptional repression can be attributed to REF-1 activities. The REF-1 family is expressed and has similar functions in both Notch-dependent and Notch-independent pathways, and this dual mode of deployment is used repeatedly to pattern the embryo. REF-1 proteins are unusual in that they contain two different bHLH domains and lack the distinguishing characteristics of Hairy/Enhancer of Split (HES) bHLH proteins that are Notch targets in other systems. Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling. |
巻・号 | 8(6) |
ページ | 867-79 |
公開日 | 2005-6-1 |
DOI | 10.1016/j.devcel.2005.03.012 |
PII | S1534-5807(05)00103-6 |
PMID | 15935776 |
MeSH | Age Factors Animals Animals, Genetically Modified Basic Helix-Loop-Helix Transcription Factors Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism* Drosophila Drosophila Proteins Embryo, Nonmammalian Fluorescent Antibody Technique / methods Gene Expression Regulation, Developmental / physiology* Membrane Proteins / physiology* Models, Biological Molecular Sequence Data Morphogenesis / physiology Mutagenesis / physiology RNA, Double-Stranded / metabolism Receptors, Notch Sequence Alignment Signal Transduction / physiology* Transcription Factors / metabolism* |
IF | 10.092 |
引用数 | 63 |
WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
リソース情報 | |
線虫 | tm275 tm458 tm284 |