論文 - 詳細
| RRC ID | 3412 |
|---|---|
| 著者 | Brock TJ, Browse J, Watts JL. |
| タイトル | Genetic regulation of unsaturated fatty acid composition in C. elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
Delta-9 desaturases, also known as stearoyl-CoA desaturases, are lipogenic enzymes responsible for the generation of vital components of membranes and energy storage molecules. We have identified a novel nuclear hormone receptor, NHR-80, that regulates delta-9 desaturase gene expression in Caenorhabditis elegans. Here we describe fatty acid compositions, lifespans, and gene expression studies of strains carrying mutations in nhr-80 and in the three genes encoding delta-9 desaturases, fat-5, fat-6, and fat-7. The delta-9 desaturase single mutants display only subtle changes in fatty acid composition and no other visible phenotypes, yet the fat-5;fat-6;fat-7 triple mutant is lethal, revealing that endogenous production of monounsaturated fatty acids is essential for survival. In the absence of FAT-6 or FAT-7, the expression of the remaining desaturases increases, and this ability to compensate depends on NHR-80. We conclude that, like mammals, C. elegans requires adequate synthesis of unsaturated fatty acids and maintains complex regulation of the delta-9 desaturases to achieve optimal fatty acid composition. |
| 巻・号 | 2(7) |
| ページ | e108 |
| 公開日 | 2006-7-1 |
| DOI | 10.1371/journal.pgen.0020108 |
| PII | 06-PLGE-RA-0099R1 |
| PMID | 16839188 |
| PMC | PMC1500810 |
| MeSH | Animals Caenorhabditis elegans Fatty Acids, Unsaturated / metabolism* Gene Expression Regulation* Green Fluorescent Proteins / chemistry Mutation Stearoyl-CoA Desaturase / metabolism Substrate Specificity |
| IF | 5.175 |
| 引用数 | 123 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1011 tm420 tm331 tm326 |