RRC ID 3420
Author Coudreuse DY, Roël G, Betist MC, Destrée O, Korswagen HC.
Title Wnt gradient formation requires retromer function in Wnt-producing cells.
Journal Science
Abstract Wnt proteins function as morphogens that can form long-range concentration gradients to pattern developing tissues. Here, we show that the retromer, a multiprotein complex involved in intracellular protein trafficking, is required for long-range signaling of the Caenorhabditis elegans Wnt ortholog EGL-20. The retromer functions in EGL-20-producing cells to allow the formation of an EGL-20 gradient along the anteroposterior axis. This function is evolutionarily conserved, because Wnt target gene expression is also impaired in the absence of the retromer complex in vertebrates. These results demonstrate that the ability of Wnt to regulate long-range patterning events is dependent on a critical and conserved function of the retromer complex within Wnt-producing cells.
Volume 312(5775)
Pages 921-4
Published 2006-5-12
DOI 10.1126/science.1124856
PII 1124856
PMID 16645052
MeSH Animals Body Patterning Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / analysis Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cell Line Gene Expression Glycoproteins / analysis Glycoproteins / genetics Glycoproteins / physiology* Humans Multiprotein Complexes / physiology* Mutation Neurons / cytology Neurons / physiology RNA Interference Signal Transduction* Transgenes Vesicular Transport Proteins / genetics Vesicular Transport Proteins / physiology Wnt Proteins / physiology* Xenopus
IF 41.846
Times Cited 179
C.elegans tm1320 tm1523