論文 - 詳細
| RRC ID | 3430 |
|---|---|
| 著者 | Grote P, Conradt B. |
| タイトル | The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
The Gli-like transcription factor TRA-1 of C. elegans promotes female development by repressing the transcription of male-specific genes. We have found that tra-1 interacts with tra-4, a previously uncharacterized gene that encodes a protein similar to the human proto-oncoprotein and transcriptional repressor PLZF. In this context, the TRA-4 protein functions with NASP-1, a C. elegans homolog of the mammalian histone chaperone NASP, and the histone deacetylase HDA-1. We also found that tra-4 is a member of the synMuv B group of genes, many of which encode homologs of components of the Drosophila Myb-Muv B transcriptional repressor complex, and that several synMuv B genes also promote female development. Based on these results, we propose that male-specific genes are repressed in C. elegans hermaphrodites by the combined action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP, and HDA-1/HDAC, and synMuv B proteins. Similar interactions may function in sex determination and developmental regulation in other species. |
| 巻・号 | 11(4) |
| ページ | 561-73 |
| 公開日 | 2006-10-1 |
| DOI | 10.1016/j.devcel.2006.07.015 |
| PII | S1534-5807(06)00342-X |
| PMID | 17011494 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Embryo, Nonmammalian Female Helminth Proteins / chemistry Helminth Proteins / genetics Helminth Proteins / metabolism* Molecular Sequence Data Sequence Homology, Amino Acid Sex Characteristics* Transcription Factors / genetics Transcription Factors / metabolism* Transgenes |
| IF | 10.092 |
| 引用数 | 30 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1489 tm1374 tm1624 |