RRC ID 3433
Author Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M.
Title C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development.
Journal Dev. Biol.
Abstract Cytoplasmic polyadenylation element-binding proteins (CPEBs) are well-conserved RNA-binding proteins, which regulate mRNA translation mainly through control of poly(A) elongation. Here, we show that CPB-3, one of the four CPEB homologs in C. elegans, positively regulates multiple aspects of oocyte production. CPB-3 protein was highly expressed in early meiotic regions of the hermaphrodite gonad. Worms deficient in cpb-3 were apparently impaired in germ cell proliferation and differentiation including sperm/oocyte switching and progression of female meiosis. We also show that cpb-3 is likely to promote the meiotic entry in parallel with gld-3, a component of one of the redundant but essential genetic pathways for the entry to and progression through meiosis. Taken together, CPEB appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression.
Volume 295(2)
Pages 689-99
Published 2006-7-15
DOI 10.1016/j.ydbio.2006.04.002
PII S0012-1606(06)00254-5
PMID 16678151
MeSH Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology* Cell Differentiation Cell Proliferation Female Genetic Speciation Germ Cells / cytology* Male Meiosis Oocytes / cytology RNA-Binding Proteins / metabolism* RNA-Binding Proteins / physiology* Spermatozoa / cytology Two-Hybrid System Techniques
IF 3.262
Times Cited 14
WOS Category DEVELOPMENTAL BIOLOGY
Resource
C.elegans tm1746