論文 - 詳細
| RRC ID | 3433 |
|---|---|
| 著者 | Hasegawa E, Karashima T, Sumiyoshi E, Yamamoto M. |
| タイトル | C. elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development. |
| ジャーナル | Dev Biol |
| Abstract |
Cytoplasmic polyadenylation element-binding proteins (CPEBs) are well-conserved RNA-binding proteins, which regulate mRNA translation mainly through control of poly(A) elongation. Here, we show that CPB-3, one of the four CPEB homologs in C. elegans, positively regulates multiple aspects of oocyte production. CPB-3 protein was highly expressed in early meiotic regions of the hermaphrodite gonad. Worms deficient in cpb-3 were apparently impaired in germ cell proliferation and differentiation including sperm/oocyte switching and progression of female meiosis. We also show that cpb-3 is likely to promote the meiotic entry in parallel with gld-3, a component of one of the redundant but essential genetic pathways for the entry to and progression through meiosis. Taken together, CPEB appears to have a conserved role in the early phase of meiosis and in the sperm/oocyte specification, in addition to its reported function during meiotic progression. |
| 巻・号 | 295(2) |
| ページ | 689-99 |
| 公開日 | 2006-7-15 |
| DOI | 10.1016/j.ydbio.2006.04.002 |
| PII | S0012-1606(06)00254-5 |
| PMID | 16678151 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology* Cell Differentiation Cell Proliferation Female Genetic Speciation Germ Cells / cytology* Male Meiosis Oocytes / cytology RNA-Binding Proteins / metabolism* RNA-Binding Proteins / physiology* Spermatozoa / cytology Two-Hybrid System Techniques |
| IF | 2.896 |
| 引用数 | 21 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1746 |