論文 - 詳細
| RRC ID | 34352 |
|---|---|
| 著者 | Kulakovskaya E, Baskunov B, Zvonarev A. |
| タイトル | The antibiotic and membrane-damaging activities of cellobiose lipids and sophorose lipids. |
| ジャーナル | J Oleo Sci |
| Abstract |
Antibiotic activity was compared for Cryptococcus humicola cellobiose lipids, the mixture of 2,3,4-О-triacetyl-β-D-glucopyranosyl-(1→4)-(6-О-acetyl-β-D-glucopyranosyl-(1→16)-2,16-dihydroxyhexodecanoic acid and 2,3,4-О-triacetyl-β-D-glucopyranosyl-(1→4)-(6-О-acetyl-β-D-glucopyranosyl-(1→16)-2,17,18-trihydroxyoctotodecanoic acid, and the commercial sophorose lipid mixture of a mono-acetylated acidic sophorose lipid and a di-acetylated acidic sophorose lipid, both containing the C18:1 fatty acid residue. The MIC values of cellobiose lipids were 0.005 and 0.04 mg/mL for Filobasidiella neoformans and Candida tropicalis, respectively. The MIC values of sophorose lipids were 1 and 15 mg/mL for F. neoformans and C. tropicalis, respectively. MIC values for some bacteria were in the range of 10-30 mg/mL for both glycolipid preparations. Both sophorose lipids and cellobiose lipids displayed a membrane-damaging activity against F. neoformans. The treatment with these glycolipids reduces the content of ATP in the cells of test cultures and results in their staining with ethidium bromide. |
| 巻・号 | 63(7) |
| ページ | 701-7 |
| 公開日 | 2014-1-1 |
| DOI | 10.5650/jos.ess14037 |
| PII | DN/JST.JSTAGE/jos/ess14037 |
| PMID | 24976613 |
| MeSH | Adenosine Triphosphate / metabolism Anti-Bacterial Agents* Antifungal Agents* Candida tropicalis / cytology Candida tropicalis / drug effects* Candida tropicalis / metabolism Cell Membrane / drug effects* Cellobiose / chemistry Cellobiose / pharmacology* Cryptococcus neoformans / cytology Cryptococcus neoformans / drug effects* Cryptococcus neoformans / metabolism Dose-Response Relationship, Drug Drug Combinations Drug Resistance, Bacterial Drug Resistance, Fungal Glucans / chemistry Glucans / pharmacology* Lipids / chemistry Lipids / pharmacology* |
| IF | 1.304 |
| 引用数 | 7 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1542 |